Fibrosing Mediastinitis Causing Ostial Coronary Artery Compression in a Young Woman

A 42-year-old woman presented with worsening angina. Electrocardiography showed ST-segment elevation in lead aVR. Coronary angiography showed 80% ostial left main coronary stenosis (AOnline Video 1) and 90% ostial right coronary stenosis (BOnline Video 2). An intraaortic balloon pump was placed, and urgent coronary artery bypass surgery was performed. Intraoperatively, the patient had a “shield-like” infiltrative whitish mass involving the aortic root, ascending aorta, and pulmonary arteries, and extrinsically compressing both coronary arteries (C). Despite extensive involvement of the aortic root and arch, cannulation of the aortic arch was feasible, and saphenous vein grafts were placed. Biopsies showed necrosis with chronic inflammatory cells, mainly lymphocytes and neutrophils with fibroblasts and extensive collagen deposition (D and E). The cause of the mass remains idiopathic despite extensive workup.

Fibrosing mediastinitis is commonly idiopathic and related to autoimmune processes, such as retroperitoneal fibrosis, Riedel’s thyroiditis, orbital pseudotumor, and Hodgkin’s disease. Histoplasmosis,Mycobacterium tuberculosis, aspergillosis, blastomycosis, Nocardia, and Wuchereria bancrofti have been identified as potential causes.

J Am Coll Cardiol. 2012;60(25):2693-2693. doi:10.1016/j.jacc.2012.04.066

About Dr.Nabil Paktin

Cardiologist , M.D.,F.A.C.C.

Posted on December 20, 2012, in Uncategorized. Bookmark the permalink. Leave a comment.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: